Windows Mobile Device Center Connection Issues with Windows 10
The latest Windows 10 PC builds have been found to have issues running Windows Mobile Device Center (WMDC). WMDC may not work with the recently released Windows 10 version 1703, or any subsequent Windows 10 versions. This support note has recommendations and troubleshooting options to address WMDC connection issues resulting from incompatibility of WMDC and Windows 10.
A Registry editing tool for the PC OS is available to address the current known issue with Windows 10 version 1703 and can be downloaded from here. Instructions on how to use it are available in the Support Note below.
Support Note last updated August 2020 to link to the WMDC installs (as Microsoft removed them from their websites).
Note: Windows 10 will install WMDC if there is an Internet connection on the PC when a connection is made to a device via USB (but it may take some time, and multiple restarts may be necessary if lots of Updates also need to be applied).