This is the response support gave:
As for the error you are seeing this is a null reference occurring within the Takeoff module where TBC is trying to save your project, but it has encountered a blank or missing value in your settings where it expects data, causing the save process to crash.
You likely have a boundary or surface assigned to a Material or Site Improvement that was recently deleted, renamed, or left unselected. TBC is looking for that "Value" and finding "Null" (nothing), which prevents the file from writing to your disk.
Please recheck your Project settings and data as well as the MSI manager for that.
You may also clean your project data using the Purge command or export your project as .vce to move your work into a fresh, clean project template