Hi Titus,
some of our clients are using SHP files, which define the tiles, including metadata information for the naming of the files and some additional meta-information about the data itself (Year, Camera, Flight Operator, etc...). In case we would go this way to offer a tiling into more systematic tiles, I would prefer this solution as you would see in before the tiling structure and you can easily share it with some other system or software.
We also offer for aerial photogrammetry the professional software solution Inpho OrthoVista which allows additional use of pixel-based tiling files, which would only need an origin point, pixel resolution size (keeping it simple and having square pixels) and the number of tiles to North, East, West, South. I would really prefer to keep it simple and have the orthos face north and not allow some rotated pixels, as this makes things much more complicated.
What solution do you use to create your 100m x 100m tiles or your 10.000 x 10.000 px tiles?